Furthermore, tryprostatin A (103) exhibited inhibitory activity over the elongation of lettuce shoots [11]. 3. CXCTD-06-6aAverage radical scavenging activity against DPPH[20]Brevianamide Q (10)CXCTD-06-6aAverage radical scavenging activity against DPPH[20]Brevianamide R (11)CXCTD-06-6aAverage radical scavenging activity against DPPH[20]Brevianamide S (12)Marine-derived in the sediment collected in the Bohai Ocean of ChinaSelective antibacterial activity[25]Brevianamide T (13)Marine-derived in the sediment collected in the Bohai Ocean of China-[25]Brevianamide U (14)Marine-derived in the sediment collected in the Bohai Ocean of China-[25]Brevianamide V (15)Marine-derived in the sediment collected in the Bohai Ocean of China-[25]Deep ocean derived CXCTD-06-6aAverage radical scavenging activity against DPPH[20]Brevianamide W (16)Deep ocean derived CXCTD-06-6aAverage radical scavenging activity against DPPH[20]5-Chlorosclerotiamide (17)Deep ocean produced from from from from from from from sp.-[32]Marine-derived in the sediment collected in the Bohai Ocean of China-[25](+)-Deoxyisoaustamide (28)from a driftwood sample-[10]Marine-derived sp.Cytotoxic activity[34]Deep-sea derived sp. SCSIO Ind09F01Anti-tuberculosis and cytotoxic activity[35]Marine-derived sp. isolated from the top of drift woodAntibacterial activity against in the marine dark brown alga SD-273-[37]Fumitremorgin B (37)Endophytic from from sp. FL25 from from a driftwood test-[10]Endophytic from sp.Cytotoxic activity[34]Marine-derived sp. from the top of driftwoodAntibacterial activity against sp. FL25 from from from from SD-273-[37]26-Hydroxyverruculogen (47)Sea sediment-derived SD-273-[37]6-Methoxyspirotryprostatin B (48)Marine-derived from a driftwood sampleWeak cytotoxicity against HL-60 PDGFD cells and A-549 cells[10]Endophytic from in the stem of sp.Average cytotoxicity in Hela and L1210 cells[32]Notoamide B (50)Marine-derived sp.Average cytotoxicity in Hela and L1210 cells[32](-)-Notoamide B (51)MF297-2-[32](+)-Notoamide B (52)NRRL 35600-[41]sp.-[32]3-sp.-[42]Notoamide D (56)Marine-derived sp.-[32]Notoamide E (57)NRRL 35600-[43]Notoamide E2 (58)Marine-derived sp.-[42]Notoamide E3 (59)Marine-derived sp.-[42]Notoamide F (60)Marine-derived sp.-[44]Marine-derived sp.-[44]Notoamide H (62)Marine-derived sp.-[44]Notoamide We (63)Marine-derived sp.Weak cytotoxicity in HeLa cells[44]Notoamide J (64)Marine-derived sp.-[44]Notoamide K (65)Marine-derived sp.-[44]Notoamide L (66)Marine-derived sp.-[45]Notoamide M (67)Marine-derived sp.-[45]Notoamide N (68)Marine-derived sp.-[45]Notoamide O (69)Marine-derived sp.-[46]Notoamide P (70)Marine-derived sp.-[46]Notoamide Q (71)Marine-derived sp.-[46]Notoamide R (72)sp.-[46]Notoamide S (73)sp.-[48]6-sp.-[48]13-Oxofumitremorgin B (76)Endophytic from from a driftwood sampleWeak cytotoxicity against A-549 cells[10]Endophytic from VKM F-691Cytotoxic and antimicrobial actions[49]Piscarinine B (80)VKM F-691Cytotoxic and antimicrobial actions[49]13-SD-273Lethal activity against brine shrimp[37]Sclerotiamide (82)KM007Moderate activity against KM007-[51]Spiro[5from NNC 55-0396 the stem of from from a driftwood test-[10]Spirotryprostatin B (88)from from from from soft coral sp.Rousing action over the growth of sprout root base of soy, buckwheat and corn[52]Spirotryprostatin Fb (93)Place endophytic in the rhizome of in the stem of (formerly MF297-2-[32]6-(IBT 19404)-[53]Taichunamide E (100)(IBT 19404)-[53]Taichunamide F (101)(IBT 19404)-[53]Taichunamide G (102)(IBT 19404)-[53]Tryprostatin A (103)Endophytic from from from from from SD-273-[37]Verruculogen TR-2 = TR-2 (106)Endophytic from SD-273-[37]Versicamide A (107)Marine-derived sp.-[45](+)-Versicolamide B (115)NRRL 35600-[41](?)-Versicolamide C (116)and in the holothurian showed inhibitory activity in the mouse cell cycle against tsFT210, and in addition inhibited tumor cell cycle arrest at G2/M with the very least inhibitory concentration (MIC) value of 0.45 M [9]. 18-Oxotryprostatin A (77) was isolated in the marine-derived fungi and found to demonstrate vulnerable cytotoxic activity against A-549 cells using a median inhibitory focus (IC50) value of just one 1.28 M [10]. This substance was also extracted from the endophytic fungi from to show plant development inhibitory activity [11]. Spirotryprostatins (87C94) had been isolated from [15]. Tryprostatin A (103) was an inhibitor from the multidrug-resistance breasts cancer proteins (BCRP) that mediated level of resistance to chemotherapeutics in breasts cancer tumor treatment [16], whereas tryprostatin B (104) was a mammalian cell-cycle inhibitor, appealing being a potential anticancer agent [17]. Furthermore, tryprostatin A (103) exhibited inhibitory activity over the elongation of lettuce shoots [11]. 3. TryptophanCTryptophan Cyclodipeptides The ditryptophan cyclodipeptides, that have two tryptophan systems, are distributed in filamentous fungi broadly, in the genera and sp specifically.Hypotensive vasodilating activity[54]3.05358Inhibitory activity in -glucosidase[68]Cyclo(l-TrpCl-Trp) (119)Endophytic in the liverwort KUFA 0702-[70]Fellutanine A 2KUFA 0702-[70]Fellutanine B (123)var. AK-40Insecticidal activity[62]Okaramine B (130)AK-40Insecticidal activity[62]Okaramine C (131)ZHN-7-07Cytotoxic activity against HL-60 cells NNC 55-0396 with IC50 worth of 0.78 M[61]Okaramine T (148)ZHN-7-07-[61]Okaramine NNC 55-0396 U (149)ZHN-7-07-[61] Open up in another window Take note: IC50, median inhibitory concentration. Amauromine (117) from sp. [54] was similar with nigrifortine (117) from [57]. Fellutanines ACD (121, 123C125), the analogs of cyclo(l-TrpCd-Trp), had been isolated in the civilizations of CBS117520. This substance acquired inhibitory activity over the cell proliferation of.