Cabozantinib is approved for the treatment of renal cell carcinoma (RCC). using the series of cabozantinibCnivolumab and 25.64 NR and months with nivolumabCcabozantinib, respectively. The difference between both of these sequences was significant only in good-risk patients statistically. In the second-line establishing, hemoglobin (Hb) amounts (HR= 2.39; 95% CI 1.24C4.60, = 0.009) and IMDC (International Metastatic Renal Cell Carcinoma Data source Consortium) group (HR = 1.72, 95% CI 1.04C2.87, = 0.037) were connected with PFS while ECOG-PS (HR = 2.33; 95%CI, 1.16C4.69, = 0.018) and Hb amounts (HR = 3.12; 95%CI 1.18C8.26, = 0.023) correlated with OS in multivariate analysis, within the third-line environment, only Hb amounts (HR = 2.72; 95%CI 1.04C7.09, = 0.042) were connected with OS. Email address details are tied to the retrospective character of the analysis.This real-world study provides evidence on the presence of prognostic factors in RCC patients receiving cabozantinib. = 0.039). Similarly, PFS was different according to ECOG-performance status (PS; 0 vs. 1 vs. 2; 10.88 months vs. 5.88 months vs. 2.66 months, 0.001, Figure 1) and hemoglobin (Hb) 12 g/dL vs. 12 g/dL (10.88 vs. 5.88 months, HR = 0.39, 95% CI 0.18C0.62, 0.001, Figure 1). Otherwise, no significant difference was found based on time from diagnosis to systemic therapy (1y vs. 1y, 11.28 vs. 7.13 months, HR = 0.62, 95% CI 0. 73C1.14, = 0.130), neutrophilia (7.76 vs. 4.01 months, HR = 0.48, 95% CI 0.13C1.01, = 0.051), thrombocytosis (7.89 vs. 6.51 months, HR = 0.50, 95% CI 0.15C1.02, = 0.055) and hypercalcemia (7.82 vs. 3.06 months, HR = 0.50, 95% GW 4869 novel inhibtior CI 0.12C1.22, = 0.106). Open in a separate window Figure 1 Progression-free survival of second-line cabozantinib according to different prognostic factors. Hb = hemoglobin; IMDC = International Metastatic Renal Cell Carcinoma Database Consortium. Interestingly, no significant differences were also found between clear-cell and non-clear-cell histology (7.89 vs. GW 4869 novel inhibtior 5.06 months, HR = 0.73, 95% CI 0.35C1.40, = 0.310), age 70y and 70y (7.89 vs. 7.13 months, HR = 0.74, 95% CI 0.37C1.41, = 0.334), gender (= 0.678), Fuhrman or WHO/ISUP grade (= 0.756) or number of metastatic sites (1 site vs. 2 sites, 7.59 vs. 7.82 months, HR = 0.99, 95% CI 0.56C1.76, = 0.987). By stratifying patients based on the site of metastasis, a significant difference was found between patients with or without bone metastases (6.51 vs. 9.86 months, HR = 0.58, 95% CI 0.31C0.98, = 0.044, Figure 1), whilst no differences were found between patients with lung (6.05 vs. 6.31 months, HR = 0.88, 95% CI 0.64C1.21, = 0.446), liver (7.59 vs. 12.3 months, HR = 1.48, 95% CI 0.73C2.81, = 0.297), lymph node (7.59 vs. GW 4869 novel inhibtior 7.89 months, HR = 1.23, 95% CI 0.71C2.16, = 0.447), or brain metastases (7.76 vs. 7.59 months, HR = 1.24, 95% CI 0.52C2.89, = 0.638). Furthermore, we analyzed the eventual prognostic role of the received first-line therapy, with any significant difference between sunitinib and pazopanib (7.89 vs. 7.82 months, HR = 1.25, 95% CI 0.70C2.38, = 0.418). Univariate analysis showed that ECOG-PS (HR = 2.47; 95% CI, 1.40C4.36, = 0.002), Hb levels (HR = 2.90; 95% CI, 1.55C5.42, 0.001), IMDC group (HR GW 4869 novel inhibtior = 1.77; 95% CI, 1.12C2.80, = 0.015) and bone metastases (HR GW 4869 novel inhibtior = 1.75; 95% CI, 1.10C3.02, = 0.047) were significantly associated with the PFS of cabozantinib, given as second-line therapy. At multivariate analysis, only Hb levels (HR = 2.39; 95% CI, 1.24C4.60, = 0.009) and IMDC group (HR = 1.72, 95% CI, 1.04C2.87, = 0.037) maintained their prognostic significance in this setting. 2.3. Overall Survival of Cabozantinib as Second-Line Therapy The median OS of cabozantinib as second-line therapy was 11.57 months (95% CI 10.90CNR, Table 3). Differently from PFS, IMDC classification was not associated with OS in the three prognostic groups (12.53 vs. 10.95 vs. 11.05 months, = 0.349, Table 3). Conversely, the median OS was significantly different according to ECOG-PS (0 vs. 1 vs. 2; 30.71 months vs. 10.95 months vs. 2.96 months, 0.001, Figure 2), Hb 12 g/dL Rabbit Polyclonal to Trk A (phospho-Tyr680+Tyr681) vs. 12 g/dL (30.71 vs. 8.42 months, HR = 0.24, 95% CI 0.10C0.44, 0.001, Figure 2), thrombocytosis (15.52 vs. 10.95 months, HR = 0.42, 95% CI 0.09C0.90, = 0.032, Figure 2) and hypercalcemia (11.08 vs. 4.37 months, HR = 0.32, 95% CI 0.04C0.60, = 0.008, Figure 2). Of note, no significant differences were found for neutrophilia (12.53 vs. 11.57 months, HR = 0.57, 95% CI 0.17C1.48, = 0.211), time from diagnosis to systemic therapy (1y vs. 1y, 11.57 vs. 11.05 months,.