Formative research into the behavioral factors surrounding HIV vaccine uptake is becoming increasingly important as progress is made in HIV vaccine development. risk behavior if they and/or their partner received an HIV vaccine. Using generalized linear mixed models, relationship-level correlates to risk compensation were examined. In bivariate analysis, risk compensation was more likely to occur between partners who have known each other for a shorter time (OR=0.95, 95% CI: 0.90-0.99, p=0.028) and between those who inject drugs have sex Complanatoside A supplier together (OR=2.52, CI: 1.05-6.04, p=0.039). In associations involving risk Complanatoside A supplier compensation, 37% involved partners who had known each other for a 12 months or less compared to only 13% of associations not involving risk compensation. Adjusting for other variables, duration (OR: 0.95, CI: 0.90-1.00 p=0.033) was associated with risk compensation intent. These analyses suggests that Complanatoside A supplier risk Complanatoside A supplier compensation may be more likely to occur in less established associations and between partners engaging in more than one type of risk behavior. These data provide further support for the need to expand steps of risk compensation in HIV vaccine preparedness studies to assess not only people will change their behavior, but also is most likely to increase risk behavior but not in which behavioral change is likely to occur. This presents a significant Complanatoside A supplier gap in knowledge about the potential impact of risk compensation on HIV vaccine initiatives. Recent network-level research using dyadic data on anticipated HIV vaccine-related risk compensation revealed that increases in risk behavior in certain relationships could impact the connectivity of the overall risk network in which individuals are embedded (Young, Halgin, DiClemente, Sterk, & Havens, 2014). While the study focused on the larger network structure, local dyadic patterns remained largely unexplored. Therefore, the purpose of the present study was to characterize the dyadic associations in which HIV vaccine-related risk compensation is most likely to occur. Methods Sample The sample consisted of 433 participants enrolled in a longitudinal study investigating HIV, HCV, and herpes-simplex 2 incidence among illicit drug users [described in detail elsewhere (Havens et al., 2013; Small, Jonas, Mullins, Halgin, & Havens, 2013)]. Eligibility criteria included being at least 18 years of age, residing in Appalachian Kentucky, and having used prescription opioids, heroin, crack/cocaine or methamphetamine to get high in the prior 30 days. Participants Rabbit Polyclonal to GK2 completed interviewer-administered questionnaires and HIV testing at baseline and in 6-month intervals thereafter. A questionnaire to examine attitudes toward HIV vaccination and risk compensation intent was administered during participants 24-month assessment; the data from this questionnaire were used for the analyses presented below. Details on the HIV vaccine survey methods have been described previously (Young, DiClemente, Halgin, Sterk, & Havens, 2014a, 2014b; Small, Halgin, et al., 2014). All participants tested HIV unfavorable at the 24-month visit. The protocol was approved by the University Institutional Review Board and a Certificate of Confidentiality was obtained. Dyadic data Respondents were asked to provide the first name and last initial of individuals with whom they had injected drugs and/or engaged in sex during the past 6 months. Each partnership constituted a risk relationship. As described elsewhere (Young, Halgin, et al., 2014), for each partner, respondents were asked about their likelihood of increasing risk behavior if they, the partner, or they their partner received an HIV vaccine. Specifically, respondents were asked three sex-related items, If [you/partner/you and partner] got an HIV vaccine that was 90% effective, would you use a condom with them… [Much less often, Less often, More often, Much more often, We wouldn’t change how often we used a condom]; and three injection-related items, If [you/partner/you and partner] got an.