Introduction HIV-associated lipodystrophy syndrome causes systemic metabolic alterations and mental distress

Introduction HIV-associated lipodystrophy syndrome causes systemic metabolic alterations and mental distress that worsen the quality of life of these patients. L4-L5 intervertebral space. Results BIA measurements of total and regional body fat were significantly correlated with those obtained by DXA (0.05 to <0.01) in HIV-positive patients. However, agreement between methods was poor as not very high ICC (intraclass correlation coefficient) values were observed. BIA and DXA showed higher ICC values in lipoatrophic patients. The visceral index obtained by BIA was correlated with total and visceral fat in L4 measured by CT scan (0.607 and 0.617, respectively, 0.01) in HIV-positive patients. The Fat Mass Ratio (FMR) calculated by BIA did not correlate or agree with DXA values. Conclusions Multi-frequency BIA could be an effective method to evaluate the evolution of total and regional fat composition in HIV-positive patients with/without GNGT1 lipoatrophy. The correlations between DXA and BIA improved in lipoatrophic individuals and in males, recommending that its effectiveness depends on fats mass, gender and additional elements probably. The visceral index acquired by BIA appears to be a reliable sign of abdominal weight problems. However, BIA didn’t fulfil the necessity for easy quantitative diagnostic equipment for lipoatrophy, and it didn’t provide adequate diagnostic cut-off ideals for this symptoms. (ICC) [17, 18]. The standard of contract is established predicated on ICC ideals from 0 to at least one 1 (Supplementary document). We’ve included both solitary and typical ICC ideals as only 1 measurement was used with DXA whereas the common of three measurements continues to be used in the situation of Tanita MC-180MA. The evaluation of receiver-operating quality (ROC) continues to be used to measure the capability of FMR determined by BIA to diagnose lipoatrophy. Lipoatrophy/lipodystrophy position was set like a FMR 1.5 relating to DXA [19]. For gender-specific analyses, lipoatrophy/lipodystrophy position was thought as a FMR 1.9 in men and 1.3 for females [15]. A worth with optimal level of sensitivity and with the best specificity feasible was selected for BIA [20, 21]. SPSS 18.0 version for B-HT 920 2HCl Home windows (SPSS, USA) and GraphPad Prism 5.0 (Graph-Pad Software program Inc., USA) had been useful for the statistical analyses. Outcomes Clinical and demographic features from the individuals All the individuals had been Caucasian (Desk 1). The three organizations had been virtually identical in virtually all guidelines shown although HIV-positive individuals had been significantly more than settings (0.01). HIV organizations had been also similar although the amount of individuals on HAART was considerably higher in the lipoatrophic group in comparison to the non-lipoatrophic group (0.05). The duration from the antiretroviral treatment was quite identical between organizations. Desk 1 Clinical and demographic features from the individuals No differences had been seen in total fats mass or fats in hands B-HT 920 2HCl and trunk between B-HT 920 2HCl your lipoatrophic and the non-lipoatrophic groups. However, a slight decrease was observed in leg fat in the lipoatrophic group (0.07). This difference reached statistical significance when fat was expressed in grams (data not shown). Total and regional fat mass measured by BIA and DXA in HIV-positive and -negative men and women Correlation coefficients obtained when compared to BIA and DXA were higher and more significant in HIV-positive patients than in non-HIV patients. Thus, in HIV-positive volunteers, a very good correlation (0.01) between both techniques was found when compared to all fat parameters. A similar tendency was observed in HIV-positive men, whereas only a significant correlation between BIA and DXA was found when measuring total fat mass (%) (0.795, 0.05) and troncular fat (%) (0.922, 0.01) in HIV-positive women. Regarding the agreement between both techniques and that described by the ICC, it is interesting to point out that both BIA and DXA showed higher ICC values when leg fat was measured (moderate concordance for control volunteers: 0.628C0.772 and good concordance for HIV-positive patients: 0.757C0.862) (Table 2). Table 2 Assessment of total and local fats mass assessed by BIA and DXA in B-HT 920 2HCl HIV-positive and HIV-negative women B-HT 920 2HCl and men Total fats mass (%) (0.786C0.880) and calf body fat (0.801C0.889) showed the best ICC values in HIV-positive men, whereas total fat mass (%) (0.665C0.799) and troncular fat (0.711C0.831) were the best in HIV-positive ladies (Desk 2). When the control volunteers had been classified relating to gender, ICC ideals had been really small in virtually all.

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