Objective: The purpose of this work was to investigate the effect

Objective: The purpose of this work was to investigate the effect of -cyclodextrin complexation around the solubility and hydrolysis rate of icariin. hydrolysis experiment showed that icariin can be transformed into baohuoside I. The optimum conditions determined were as follows: pH 5.0, 50C, the ratio of cellulase/substrate (0.6), NVP-BEP800 the concentration of icariin 20 mg/ml, and reaction time 12 h. Under these enzymatic conditions, 98.2% transforming rate of baohuoside I from icariin in inclusion complexes CalDAG-GEFII was acquired. Summary The aqueous solubility and enzymatic hydrolysis rate of icariin were improved owing to the inclusion complexation. (Berberidaceae). Its molecular method is definitely C27H30O10 and molecular excess weight is definitely 514 Da. It has been confirmed to display many bioactivities or and model. Part 1: Natural inhibitors for protein tyrosine kinase triggered by hypoxia/reoxygenation in cultured human being umbilical vein endothelial cells. Planta Med. 2000;66:114C8. [PubMed] 8. Zhang YW, Morita I, Zhang L, Shao G, Yao XS, Murota S. Screening of anti-hypoxia/reoxygenation providers by an method. Part 2: Inhibition of tyrosine kinase activation prevented hypoxia/reoxygenation-induced injury in endothelial space junctional intercellular communication. Planta Med. 2000;66:119C23. [PubMed] 9. Xia Q, Xu DJ, Huang ZG, Liu JJ, Wang XQ, Wang X, et al. Preparation of icariside II from icariin by enzymatic hydrolysis method. Fitoterapia. 2010;81:437C42. NVP-BEP800 [PubMed] 10. Blanco J, Jato JL, Otero F, Aguian S. Influence of method of preparation on inclusion complexes of naproxen with different cyclodextrin. Drug Dev Ind Pharm. 1991;17:943C57. 11. Palmieri GF, Angeli DG, Giovannucci G, Martelli S. Inclusion of methoxybutropate in -and hydroxypropyl–cyclodextrins: Assessment of preparation methods. Drug Dev NVP-BEP800 Ind Pharm. 1997;23:27C37. 12. Castillo JA, Canales JP, Garcia JJ, Lastres JL, Bolas F, Torrado JJ. Preparation and characterization of albendazole–cyclodextrin complexes. Drug Dev Ind Pharm. 1999;25:1241C8. [PubMed] 13. Rebecca LC, Lee AM, Imran A. The energy of cyclodextrins for enhancing oral bioavailability. J Control Launch. 2007;123:78C99. [PubMed] 14. Martin Del Valle EM. Cyclodextrins and their uses: A review. Process Biochem. 2004;39:1033C46. 15. Mamata S, Rohit S, Banerjee UC. Biotechnological applications of cyclodextrins. Biotechnol Adv. 2002;20:341C59. [PubMed] 16. Corti G, Capasso G, Maestrelli F, Cirri M, Mura P. Physical-chemical characterization of binary systems of metformin hydrochloride with triacetyl-beta-cyclodextrin. J Pharm Biomed Anal. 2007;45:480C6. [PubMed] 17. Marco B, Elisabetta R, Paolo F, Francesco T. Preparation and evaluation of the antiviral activity of the Acyclovir complex of a cyclodextrin/poly(amidoamine) copolymer. J Control Launch. 2008;126:17C25. [PubMed] 18. Schulein M. Protein executive of cellulases. Biochim Biophys Acta. 2000;1543:239C52. [PubMed] 19. Li CZ, Makoto Y, Kimitoshi F, Katsumi N. Characterization and immobilization of liposome-bound cellulase for hydrolysis of insoluble cellulose. Bioresour Technol. 2007;98:1366C72. [PubMed] 20. Reeta RS, Rajeev KS, Anil KP, Christian L, Ashok P. Advancement and comparative profiles in the production systems using solid-state and submerged fermentation for microbial cellulases. Enzyme Microb Technol. 2010;46:541C5. 21. Bilensoy E, C?rpanl? Y, Sen M, Do?an AL, Cal? S. Thermosensitive mucoadhesive gel formulation loaded with 5-Fu: Cyclodextrin complex for HPV-induced cervical malignancy. J Incl Phenom Macrocycl NVP-BEP800 Chem. 2007;57:363C70. 22. Calderini, Pessine FB. Synthesis and characterization of inclusion complex of the vasodilator drug minoxidil with -cyclodextrin. J Incl Phenom Macrocycl Chem. 2008;60:369C77. 23. Cevher E, Sensoy D, Zloh M, Mulazimoglu L. Preparation and characterisation of natamycin: R-cyclodextrin inclusion complex and its evaluation in vaginal mucoadhesive formulations. J Pharm Sci. 2008;97:4319C35. [PubMed] 24. Sansone F, Picerno P, Mencherini T. Flavonoid microparticles by spray-drying: Influence of enhancers of the dissolution rate on properties and stability. J Food Eng. 2011;103:188C96. 25. Liaset B, Julshamn K, Espe M. Chemical composition and theoretical nutritional evaluation of the produced fractions from enzymic hydrolysis of salmon frames with Protamex? Process Biochem. 2003;38:1747C59. 26. Rosenthal A, Pyle D, Niranjan K, Gilmour S, Trinca L. Combined effect of operational variables and enzyme activity on aqueous enzymatic extraction of oil and protein from soybean. Enzyme Microb Technol. 2001;28:499C509. [PubMed].

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