Terminal differentiation of epidermal keratinocytes is usually inhibited by 1 microM retinoic acid, a concentration which induces differentiation in a number of cell types, including F9 teratocarcinoma cells. than enhanced, in their ability to undergo morphological and biochemical features of differentiation. These findings demonstrate a direct and hitherto unrecognized part for RARs and RXRs in positively as well as negatively regulating epidermal differentiation. Additionally, our studies lengthen those of Espeseth et al. (Genes Dev. 3:1647-1656, 1989), indicating a 3-Methyladenine kinase inhibitor novel RAR function independent of the E/F website. Full text Full text is available like a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.9M), or click on a page image below to browse page by page. Links to PubMed will also be available for Selected Recommendations.? 4862 4863 4864 4865 4866 4867 4868 4869 4870 4871 ? Images in this article Image br / on p.4865 Image br / on 3-Methyladenine kinase inhibitor p.4867 3-Methyladenine kinase inhibitor Image br / on p.4868 Image br / on p.4868 Rabbit Polyclonal to MEN1 Image br / on p.4869 Click on the image to see a larger version. Selected.