The qRT-PCR positive admitted cases were considered as cases, and qRT-PCR negative cases were considered as controls. bad instances were considered as regulates. Data were HUP2 came into in Microsoft Excel format and analyzed by statistical method to obtain association. Results Consecutively acquired 5000 qRT-PCR positive individuals (instances) and 11,700 (settings) were included in the present study. The mean age of instances was higher (54.24 vs. 34. 67) than the settings. Among the cases, the highest quantity (2379; 47.6%) of samples belonged to A blood group followed by B (1278; 25.6%) while among the control group O blood group had the highest prevalence (4215; 36%). Blood group DBCO-NHS ester 2 A experienced a higher odd of screening positive (Odds percentage-2.552; CI 2.381C2.734; valuevaluevalue of? ?0.00001. On the other hand, Abdominal blood group experienced no significant difference in admission of instances to ICU or wards. Blood group A is definitely associated with higher risk of ICU admission (Odds percentage- 1.699; 95% CI 1.515C1.905) while all other blood groups have DBCO-NHS ester 2 a lower risk (Table ?(Table33). Table 3 Distribution of instances as per their admission status value /th th align=”remaining” rowspan=”1″ colspan=”1″ Odds percentage br / (95% CI) /th /thead A806 (33.9)1573 (66.1)9.112? ?0.00011.699 (1.515C1.905)B600 (46.9)678 (53.1)5.426? ?0.00010.702 (0.617C0.798)O551 (46.9)623 (53.1)5.117? ?0.00010.709 (0.622C0.809)AB69 (40.8)100 (59.2)0.083?=?0.9340.987(0.723C1.353)Total2026 (40.5)2974 (59.5) Open in a separate window The individuals were further divided as per the Ct value which is an indirect measure of viral load. More than half of instances (53.9%) were having low Ct value denoting a high viral weight; moderate Ct value (20C28) experienced the minimum quantity (15.4%) of instances. Blood organizations A, B showed a higher proportion of instances in low Ct group; blood group A showing the highest percentage (1553, 65.3%). On the other hand, O and Abdominal blood groups experienced higher percentage of samples from high Ct (Fig.?2). Open in a separate windowpane Fig. 2 Distribution of instances as per their Ct ideals in qRT-PCR for SARS-COV2 Conversation The COVID-19 pandemic offers till right now grasped 190,597,409 confirmed instances all over the world including 4093, 145 deaths and figures are rising daily [10]. Knowing the important risk factors come in handy to identify the at risk population, to add new precautions and judicious allocation of the available resources to prevent the wide spread illness and mortality. There is a dearth of knowledge on demographic and medical risk element that settings the susceptibility to SARS CoV-2 illness and mortality. The risk factors recognized till date include age, sex, few chronic conditions and laboratory findings. [11]. ABO gene is definitely highly pleomorphic and differs widely across geographies and ancestry. This consists of A and B antigens on reddish cell surface encoded by two dominating and two recessive alleles located on chromosome 9q34.1C34.2 [12]. These antigens will also be indicated on epithelial cells, platelets, vascular endothelial cells and neurons [13]. ABO antibodies are part of the innate immune system against parasites, bacteria and enveloped viruses, and these also act as receptors for many immune and inflammatory reactions. [4, 14]. In our study, mean age of DBCO-NHS ester 2 instances was higher than the settings (54.24 vs. 34. 67). Most of our instances belonged to age group 51C60. In additional similar studies [3, 15, 16], age has been defined as a risk element as well most common age group becoming the fifties. This is DBCO-NHS ester 2 probably due to the fact that this is the.